Up to 60 firefighters battled to extinguish a blaze that broke out on the thatch roof of a Grade 2 listed cottage near Faringdon.
The raging inferno broke out at 7.20pm on Saturday as it ripped through the cottage in the hamlet of Knighton.
Ten fire engines and four specialist support vehicles from Oxfordshire County Council Fire & Rescue Service and Dorset & Wiltshire Fire & Rescue Service were deployed.
The roof is understood to have been completely destroyed.
Incident commander, group manager Mike Adcock said: “Thatch fires take a lot of firefighters to tackle the fire, as we need to act quickly to stop the fire spreading and save as many items from the house as soon as possible. We do this by working in teams and take great care in retrieving valuables and protecting furniture from the fire and water, firefighters worked tirelessly together to achieve this.”
The cause is being investigated by specialist fire investigators.
South Central Ambulance Service and the British Red Cross were also on scene supporting the fire crews and the occupiers.